ITM2B anticorps

N° du produit ABIN113338

Cet anticorps Poulet Polyclonal détecte spécifiquement ITM2B dans IHC (fro). Il présente une réactivité envers Humain.

Aperçu rapide pour ITM2B anticorps (ABIN113338)

Antigène: ITM2B (Integral Membrane Protein 2B (ITM2B))

Reactivité: Humain

Hôte: Poulet

Clonalité: Polyclonal

Conjugué: Cet anticorp ITM2B est non-conjugé

Application: Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-ITM2B anticorps

Séquence: CSRTVKKNII EEN

Specificité: The antibody recognizes the typical amyloid deposits in brains of patients suffering from the disease. This antibody has been developed against the carboxy terminal extracellular sequence of the mutated BRI protein.

Purification: Affinity chromatography.

Immunogène: Peptide coupled to carrier protein.

Information d'application

Indications d'application: Suitable for Immunohistochemistry on frozen sections. Suggested positive control: pathological brain sections. (Not recommended in Western blots).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg /ml

Buffer: PBS, pH 7.2, containing 0.09 % sodium azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 2-8 °C (Lyophilized) or reconstituted in small aliquots at -20 °C.

Détails sur ITM2B

Antigène: ITM2B (Integral Membrane Protein 2B (ITM2B))

Autre désignation: ITM2B

Sujet: The mutated BRI protein (ITM2B) was identified in patients with familial British dementia. The unusual 277 residue precursor protein releases a 34-residue amyloidogenic peptide by the action of the protease furin, leading to the deposition of a protein fragment that seems to be involved in the pathogenesis of familial British dementia.Synonyms: BRI, BRI2, ITM2B, Integral membrane protein 2B, Transmembrane protein BRI

ID gène: 9445

NCBI Accession: NP_068839

UniProt: Q9Y287